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  • The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in adults with a body mass index (BMI) greater than 27, given that they also have problems with weight-related health problems such as Tupe2 diabestes, high cholesterol levels and/or hypertension (high blood pressure levels).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so that as an aid to stopping smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle that includes a reduced-calorie exercise and dieting, Contrave provides another treatment option for chronic weight loss for people who are obese or are overweight and still have at least one weight-related health.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular physical exercise. Results from a clinical study that enrolled patients without diabetes indicated that patients had the average weight loss of 4.1% in contrast to participants who have been given placebos) throughout a 12- month period, while a separate study involving patients with diabetes type 2 had a normal weight loss of 2% over treatment with placebo at twelve months.

    Using two separate drugs to shed pounds can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the people who go through it you need to err assisting caution and let the FDA do its job and demand some study be done so your public knows the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies have been in business to generate income and that they would say everything to keep people on his or her medications.

    Researchers discovered that participants investing in this drug to get a year, lost weight within a month and have kept the body weight off during the entire 56 weeks with the study. Contrave is often a combination in the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which can be made up of more than one active ingredient, which can make them more effective and safer.

    Combo-pilling is the newest fad or in addition to this the newest to come under scrutiny and therefore it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills has become popular will be the fact that as of right now there aren't long term prescription weightloss pills that have been licensed by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be licensed by the FDA.

    Seizures are a side effect with Contrave and must not be taken in those with seizure disorders. The drug can also raise blood pressure levels and heart rate, and must not be used in people with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug.

    The FDA also warned that Contrave can raise blood pressure and pulse rate and must not be used in patients with uncontrolled high blood pressure levels, and also by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients having a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients for the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking.

    Acamprosate also actively works to eliminate the desire to drink by eliminating the the cravings for alcohol consumption. The major difference between Naltrexone and Acamprosate is Acamprosate is not yet obtainable in the United States. While it has been widely studied in Europe the exact chemical reason why it works continues to be unknown. It is belief that it disturbs receptors inside the brain which process glutamate, which in place alters just how ones body reacts to alcohol intake. Several of the European research has revealed a lot of promise with Acamprosate in this some of the patients had a nearly double success rate for staying sober.